Early predictors of corticosteroid response in acute severe autoimmune hepatitis: a nationwide multicenter study.

ABSTRACT:

Background and aims

To assess whether corticosteroids improve prognosis in patients with AS-AIH, and to identify factors at therapy initiation and during therapy predictive of the response to corticosteroids.

Methods

This was a retrospective cohort study including all patients with AS-AIH admitted to 13 tertiary centres from January 2002 to January 2019. The composite primary outcome was death or liver transplantation within 90 days of admission. Kaplan-Meier and Cox regression methods were used for data analysis.

Results

Of 242 consecutive patients enrolled (mean age [SD] 49.7 [16.8] years), 203 received corticosteroids. Overall 90-day transplant-free survival was 61.6% (95% confidence interval [CI] 55.4-67.7). Corticosteroids reduced the risk of a poor outcome (adju

SUBMITTER: Tellez L 

PROVIDER: S-EPMC9324977 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature