Dataset Information

The rs8506 TT Genotype in lincRNA-NR_024015 Contributes to the Risk of Sepsis in a Southern Chinese Child Population.

ABSTRACT:

Background

Sepsis is a highly life-threatening heterogeneous syndrome and a global health burden. Studies have shown that many genetic variants could influence the risk of sepsis. Long non-coding RNA lincRNA-NR_024015 may participate in functional alteration of endothelial cell via vascular endothelial growth factor (VEGF) signaling, whereas its relevance between the lincRNA-NR_024015 polymorphism and sepsis susceptibility is still unclear.

Methods

474 sepsis patients and 678 healthy controls were enrolled from a southern Chinese child population in the present study. The polymorphism of rs8506 in lincRNA-NR_024015 was determined using Taqman methodology.

Results

Overall, a significant association was found between rs8506 polymorphism and the risk of sepsis disease (TT vs. CC/CT: adjusted OR = 1.751, 95%CI = 1.024-2.993, P = 0.0406). In the stratified analysis, the results suggested that the carriers of TT genotypes had a significantly increased sepsis risk among the children aged 12-60 months, females, early-stage sepsis and survivors (TT vs. CC/CT: OR_age = 2.413; OR_female = 2.868; OR_sepsis = 2.533; OR_survivor = 1.822; adjusted for age and gender, P < 0.05, respectively).

Conclusion

Our study indicated that lincRNA-NR_024015 rs8506 TT genotype might contribute to the risk of sepsis in a southern Chinese child population. Future research is required to elucidate the possible immunoregulatory mechanisms of this association and advance the development of novel biomarkers in sepsis.

SUBMITTER: Li J

PROVIDER: S-EPMC9326103 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

The rs8506 TT Genotype in <i>lincRNA-NR_024015</i> Contributes to the Risk of Sepsis in a Southern Chinese Child Population.

Li Jinqing J Zhou Huazhong H Wei Bing B Che Di D Xu Yufen Y Pi Lei L Fu Lanyan L Hong Jie J Gu Xiaoqiong X

Frontiers in public health 20220713

<h4>Background</h4>Sepsis is a highly life-threatening heterogeneous syndrome and a global health burden. Studies have shown that many genetic variants could influence the risk of sepsis. Long non-coding RNA <i>lincRNA-NR_024015</i> may participate in functional alteration of endothelial cell <i>via</i> vascular endothelial growth factor (VEGF) signaling, whereas its relevance between the <i>lincRNA-NR_024015</i> polymorphism and sepsis susceptibility is still unclear.<h4>Methods</h4>474 sepsis ...[more]

PMID: 35910890

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