The anti-parasitic drug miltefosine suppresses activation of human eosinophils and ameliorates allergic inflammation in mice.

ABSTRACT:

Background and purpose

Miltefosine is an alkylphosphocholine drug with proven effectiveness against various types of parasites and cancer cells. Miltefosine is not only able to induce direct parasite killing but also modulates host immunity, for example by reducing the severity of allergies in patients. To date, there are no reports on the effect of miltefosine on eosinophils, central effector cells involved in allergic inflammation.

Experimental approach

We tested the effect of miltefosine on the activation of human eosinophils and their effector responses in vitro and in mouse models of eosinophilic migration and ovalbumin-induced allergic lung inflammation.

Key results

The addition of miltefosine suppressed several eosinophilic effector reactions such as CD11b up-r

SUBMITTER: Knuplez E 

PROVIDER: S-EPMC9328393 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature