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Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks.

ABSTRACT: Point-of-care (POC) biochemical sensors have found broad applications in areas ranging from clinical diagnosis to environmental monitoring. However, POC sensors often suffer from poor sensitivity. Here, we synthesized a metal-organic framework, where the ligand is the aggregation-induced emission luminogen (AIEgen), which we call metal-AIEgen frameworks (MAFs), for use in the ultrasensitive POC biochemical sensors. MAFs process a unique luminescent mechanism of structural rigidity-enhanced emission to achieve a high quantum yield (~99.9%). We optimized the MAFs to show 10²- to 10³-fold enhanced sensitivity for a hydrogel-based POC digital sensor and lateral flow immunoassays (LFIA). MAFs have a high affinity to directly absorb proteins, which can label antibodies for immunoassays. MAFs-based LFIA with enhanced sensitivity shows robust serum detection for POC clinical diagnosis.

SUBMITTER: Zhang J

PROVIDER: S-EPMC9328688 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks.

Zhang Jiangjiang J Li Ying Y Chai Fengli F Li Qizhen Q Wang Dou D Liu Liping L Tang Ben Zhong BZ Jiang Xingyu X

Science advances 20220727 30

Point-of-care (POC) biochemical sensors have found broad applications in areas ranging from clinical diagnosis to environmental monitoring. However, POC sensors often suffer from poor sensitivity. Here, we synthesized a metal-organic framework, where the ligand is the aggregation-induced emission luminogen (AIEgen), which we call metal-AIEgen frameworks (MAFs), for use in the ultrasensitive POC biochemical sensors. MAFs process a unique luminescent mechanism of structural rigidity-enhanced emiss ...[more]

PMID: 35895821

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