Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women.

ABSTRACT:

Importance

Accelerated biological aging is associated with decreased physical capability and cognitive functioning, which are associated with increased risk of morbidity and mortality.

Objective

We investigated associations between epigenetic age acceleration (EAA), a biomarker associated with aging, and healthy longevity among older women.

Design, setting, and participants

This cohort study was a secondary analysis of participants in the Women's Health Initiative (WHI) who were eligible to survive to age 90 years by September 30, 2020. Participants were located in multiple centers. This study was restricted to women with genome-wide DNA methylation data, generated from baseline blood samples within 3 WHI ancillary studies. Median (IQR) follow-up times from baseline w

SUBMITTER: Jain P 

PROVIDER: S-EPMC9331104 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature