Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents.

ABSTRACT:

Aims

Coronary artery stents have profound effects on arterial function by altering fluid flow mass transport and wall shear stress. We developed a new integrated methodology to analyse the effects of stents on mass transport and shear stress to inform the design of haemodynamically-favourable stents.

Methods and results

Stents were deployed in model vessels followed by tracking of fluorescent particles under flow. Parallel analyses involved high-resolution micro-computed tomography scanning followed by computational fluid dynamics simulations to assess wall shear stress distribution. Several stent designs were analysed to assess whether the workflow was robust for diverse strut geometries. Stents had striking effects on fluid flow streamlines, flow separation or funnelling,

SUBMITTER: Boldock L 

PROVIDER: S-EPMC9333229 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature