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Update on lymphocyte-activation gene 3 (LAG-3) in cancers: from biological properties to clinical applications.

ABSTRACT:

Abstract

Immunotherapy that targets checkpoints, especially programmed cell death protein 1 and programmed cell death ligand 1, has revolutionized cancer therapy regimens. The overall response rate to mono-immunotherapy, however, is limited, emphasizing the need to potentiate the efficacy of these regimens. The functions of immune cells are modulated by multiple stimulatory and inhibitory molecules, including lymphocyte activation gene 3 (LAG-3). LAG-3 is co-expressed together with other inhibitory checkpoints and plays key roles in immune suppression. Increasing evidence, particularly in the last 5 years, has shown the potential of LAG-3 blockade in anti-tumor immunity. This review provides an update on the biological properties and clinical applications of LAG-3 in cancers.

SUBMITTER: Zhao L

PROVIDER: S-EPMC9337260 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Update on lymphocyte-activation gene 3 (LAG-3) in cancers: from biological properties to clinical applications.

Zhao Lishu L Wang Hao H Xu Kandi K Liu Xinyue X He Yayi Y

Chinese medical journal 20220520 10

<h4>Abstract</h4>Immunotherapy that targets checkpoints, especially programmed cell death protein 1 and programmed cell death ligand 1, has revolutionized cancer therapy regimens. The overall response rate to mono-immunotherapy, however, is limited, emphasizing the need to potentiate the efficacy of these regimens. The functions of immune cells are modulated by multiple stimulatory and inhibitory molecules, including lymphocyte activation gene 3 (LAG-3). LAG-3 is co-expressed together with other ...[more]

PMID: 35170503

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