A framework For brain atlases: Lessons from seizure dynamics.

ABSTRACT: Brain maps, or atlases, are essential tools for studying brain function and organization. The abundance of available atlases used across the neuroscience literature, however, creates an implicit challenge that may alter the hypotheses and predictions we make about neurological function and pathophysiology. Here, we demonstrate how parcellation scale, shape, anatomical coverage, and other atlas features may impact our prediction of the brain's function from its underlying structure. We show how network topology, structure-function correlation (SFC), and the power to test specific hypotheses about epilepsy pathophysiology may change as a result of atlas choice and atlas features. Through the lens of our disease system, we propose a general framework and algorithm for atlas selection. This fr

SUBMITTER: Revell AY 

PROVIDER: S-EPMC9342687 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature