Using Glycated Albumin and Stimulated C-Peptide to Define Partial Remission in Type 1 Diabetes.

ABSTRACT:

Objective

To propose a new definition of partial remission (PR) for patients with type 1 diabetes (T1D) of all-ages using insulin dose and glycated albumin (GA), and find the optimal cut-off values for stimulated C-peptide to diagnose PR in different age-groups.

Research design and methods

Patients with newly diagnosed T1D (n=301) were included. GA/insulin dose was used to diagnose PR, and insulin dose-adjusted glycated albumin (IDAGA) was proposed to facilitate clinical application. The optimal diagnostic levels of IDAGA and stimulated C-peptide were determined in different age-groups (≤ 12y, 12-18y and ≥ 18y). Furthermore, the diagnostic consistency between different PR definitions was studied.

Results

GA≤ 23%/insulin dose ≤ 0.5u/kg/day was used to define PR, and ID

SUBMITTER: Shi M 

PROVIDER: S-EPMC9344919 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature