Dataset Information

Serological and Molecular Study of the Duffy Blood Group among Malarial Endemic Region Residents in Brazil.

ABSTRACT:

Background

The atypical chemokine receptor 1 (ACKR1) gene encodes the Duffy blood group antigens in two allelic forms: FY*A (FY*01) and FY*B (FY*02), which define the Fy(a+b-), Fy(a-b+), and Fy(a+b+) phenotypes. FY*BES (FY*02N.01) is a single T to C substitution at nucleotide -67 that prevents the FY*B from being expressed in red blood cells (RBCs).

Methods

We evaluated 250 residents from a Brazilian malarial endemic region (RsMR). All individuals were phenotyped for Fya and Fyb antigens and genotyped for FY*A, FY*B, FY*B SE , and FY*B weak alleles.

Results

Among the 250 individuals, 209 (83.6%) reported previous malaria infection, and 41 (16.4%) did not. The Fy(a+b+) phenotype was present in 97/250 (38.8%), while the Fy(a-b-) was present in 7/250 (2.8%). The FY*A/FY*B was found in 130/250 (52%) and the FY*A/FY*A in 45/250 (18%). The c.1-67>TC was present, in homozygosity, in 11/250 (4.4%). Among 34 individuals with the Fy(a+b-) and FYA*/FYB* mutations, 4/34 (11.8%) had homozygosity for the c.1-67T>C. One individual presented the Fy(a+b-), FY*A/FY*B, and c.1-67T>C in homozygosis, whereas the other presented the Fy(a+b-), FY*A/FY*A, and c.1-67T>C in heterozygosis.

Conclusions

We reported a low prevalence of the Fy(a-b-) in persons who had previously been infected with Plasmodium vivax (67.5%). We observed that 102/141 (72.3%) individuals expressing the Fyb antigen had a P. vivax infection, indicating the importance of the Fyb antigen, silenced by a c.1-67T>C mutation in homozygosis, in preventing the P. vivax infection. We showed that the c.1-67T>C mutation in the FY*A did not silence the FY*A expression on RBCs.

SUBMITTER: Langhi Junior D

PROVIDER: S-EPMC9344938 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Serological and Molecular Study of the Duffy Blood Group among Malarial Endemic Region Residents in Brazil.

Langhi Júnior Dante D Albuquerque Sérgio S Serafim Rui R Duarte Gustavo de Carvalho GC Covas Dimas Tadeu DT Bordin José O JO

Revista da Sociedade Brasileira de Medicina Tropical 20220805

<h4>Background</h4>The atypical chemokine receptor 1 (ACKR1) gene encodes the Duffy blood group antigens in two allelic forms: FY*A (FY*01) and FY*B (FY*02), which define the Fy(a+b-), Fy(a-b+), and Fy(a+b+) phenotypes. FY*BES (FY*02N.01) is a single T to C substitution at nucleotide -67 that prevents the FY*B from being expressed in red blood cells (RBCs).<h4>Methods</h4>We evaluated 250 residents from a Brazilian malarial endemic region (RsMR). All individuals were phenotyped for Fya and Fyb a ...[more]

PMID: 35946633

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Dataset Information

Serological and Molecular Study of the Duffy Blood Group among Malarial Endemic Region Residents in Brazil.

Background

Methods

Results

Conclusions

Publications

Serological and Molecular Study of the Duffy Blood Group among Malarial Endemic Region Residents in Brazil.

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