Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer.

ABSTRACT:

Background

Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic significance of tumour cell-T cell co-localisation and T cell densities.

Methods

We analysed CD3 and CD8 immunohistochemistry in a study cohort of 983 colorectal cancer patients and a validation cohort (N = 246). Individual immune and tumour cells were identified to calculate T cell densities (to derive T cell density score) and G-cross function values, estimating the likelihood of tumour cells being co-located with T cells within 20 µm radius (to derive T cell proximity score).

Results

High T cell proximity score associated with longer cancer-speci

SUBMITTER: Elomaa H 

PROVIDER: S-EPMC9345858 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature