Dataset Information

Relationship between consolidation tumor ratio and tumor-infiltrating lymphocytes in small-sized lung adenocarcinoma.

ABSTRACT:

Background

Consolidation tumor ratio (CTR) is associated with cancer progression and histological invasiveness in lung adenocarcinoma (LAD). However, little is known about the association between CTR and immune-related factors, including tumor-infiltrating lymphocytes (TILs) density or tumor expression of programmed death ligand 1 (PD-L1) and indoleamine 2,3-dioxygenase 1 (IDO1) in small-sized LAD.

Methods

This study included 258 patients with LAD (<3 cm) who underwent surgery. Patients were assigned to four groups: CTR = 0; 0 < CTR <0.5; 0.5 ≤ CTR <1 (ground-glass opacity [GGO] group); and CTR = 1 (pure-solid group). CD4⁺ , CD8⁺ , and FoxP3⁺ TIL density and PD-L1 and IDO1 tumor expression were assessed by immunohistochemistry.

Results

Among the GGO group, CD8⁺ and FoxP3⁺ TIL density increased significantly with increasing CTR (p < 0.001 and p < 0.001, respectively). Moreover, PD-L1 and IDO1 expression was significantly higher in the pure-solid group than in the GGO group (p < 0.001 and p < 0.001, respectively).

Conclusions

CTR was correlated with the abundance of CD8⁺ and FoxP3⁺ TILs in the GGO group. PD-L1 and IDO1 positivity rates were significantly higher in the pure-solid group than in the GGO group. Increased CTR may be correlated with immunosuppressive condition.

SUBMITTER: Ono Y

PROVIDER: S-EPMC9346188 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Relationship between consolidation tumor ratio and tumor-infiltrating lymphocytes in small-sized lung adenocarcinoma.

Ono Yuki Y Tagawa Tetsuzo T Kinoshita Fumihiko F Haratake Naoki N Takada Kazuki K Kohno Mikihiro M Takenaka Tomoyoshi T Kamitani Takeshi T Shimokawa Mototsugu M Oda Yoshinao Y Mori Masaki M Yoshizumi Tomoharu T

Thoracic cancer 20220706 15

<h4>Background</h4>Consolidation tumor ratio (CTR) is associated with cancer progression and histological invasiveness in lung adenocarcinoma (LAD). However, little is known about the association between CTR and immune-related factors, including tumor-infiltrating lymphocytes (TILs) density or tumor expression of programmed death ligand 1 (PD-L1) and indoleamine 2,3-dioxygenase 1 (IDO1) in small-sized LAD.<h4>Methods</h4>This study included 258 patients with LAD (<3 cm) who underwent surgery. Pa ...[more]

PMID: 35791738

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Dataset Information

Relationship between consolidation tumor ratio and tumor-infiltrating lymphocytes in small-sized lung adenocarcinoma.

Background

Methods

Results

Conclusions

Publications

Relationship between consolidation tumor ratio and tumor-infiltrating lymphocytes in small-sized lung adenocarcinoma.

Similar Datasets

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