Relationship between consolidation tumor ratio and tumor-infiltrating lymphocytes in small-sized lung adenocarcinoma.

ABSTRACT:

Background

Consolidation tumor ratio (CTR) is associated with cancer progression and histological invasiveness in lung adenocarcinoma (LAD). However, little is known about the association between CTR and immune-related factors, including tumor-infiltrating lymphocytes (TILs) density or tumor expression of programmed death ligand 1 (PD-L1) and indoleamine 2,3-dioxygenase 1 (IDO1) in small-sized LAD.

Methods

This study included 258 patients with LAD (<3 cm) who underwent surgery. Patients were assigned to four groups: CTR = 0; 0 < CTR <0.5; 0.5 ≤ CTR <1 (ground-glass opacity [GGO] group); and CTR = 1 (pure-solid group). CD4⁺ , CD8⁺ , and FoxP3⁺ TIL density and PD-L1 and IDO1 tumor expression were assessed by immunohistochemistry.

Results

SUBMITTER: Ono Y 

PROVIDER: S-EPMC9346188 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature