Crystal Engineering of Ionic Cocrystals Sustained by the Phenol-Phenolate Supramolecular Heterosynthon.

ABSTRACT: Although crystal engineering strategies are generally well explored in the context of multicomponent crystals (cocrystals) formed by neutral coformers (molecular cocrystals), cocrystals comprised of one or more salts (ionic cocrystals, ICCs) are understudied. We herein address the design, preparation, and structural characterization of ICCs formed by phenolic moieties, a common group in natural products and drug molecules. Organic and inorganic bases were reacted with the following phenolic coformers: phenol, resorcinol, phloroglucinol, 4-methoxyphenol, and 4-isopropylphenol. Nine ICCs were crystallized, each of them sustained by the phenol-phenolate supramolecular heterosynthon (PhOH···PhO^-). Such ICCs are of potential utility, and there are numerous examples of phenolic compou

SUBMITTER: Jin S 

PROVIDER: S-EPMC9347308 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature