Dataset Information

Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.

ABSTRACT:

Background

Folate-mediated 1-carbon metabolism requires several nutrients, including vitamin B6. Circulating biomarker concentrations indicating high vitamin B6 status are associated with a reduced risk of colorectal cancer (CRC). However, little is known about the effect of B6 status in relation to clinical outcomes in CRC patients.

Objectives

We investigated survival outcomes in relation to vitamin B6 status in prospectively followed CRC patients.

Methods

A total of 2031 patients with stage I-III CRC participated in 6 prospective patient cohorts in the international FOCUS (folate-dependent 1-carbon metabolism in colorectal cancer recurrence and survival) Consortium. Preoperative blood samples were used to measure vitamin B6 status by the direct marker pyridoxal 5'-phosphate (PLP), as well as the functional marker HK-ratio (HKr)[3'-hydroxykynurenine: (kynurenic acid + xanthurenic acid + 3'-hydroxy anthranilic acid + anthranilic acid)]. Using Cox proportional hazards regression, we examined associations of vitamin B6 status with overall survival (OS), disease-free survival (DFS), and risk of recurrence, adjusted for patient age, sex, circulating creatinine concentrations, tumor site, stage, and cohort.

Results

After a median follow-up of 3.2 y for OS, higher preoperative vitamin B6 status as assessed by PLP and the functional marker HKr was associated with 16-32% higher all-cause and disease-free survival, although there was no significant association with disease recurrence (doubling in PLP concentration: HROS, 0.68; 95% CI: 0.59, 0.79; HRDFS, 0.84; 95% CI: 0.75, 0.94; HRRecurrence, 0.96; 95% CI: 0.84, 1.09; HKr: HROS, 2.04; 95% CI: 1.67, 2.49; HRDFS, 1.56; 95% CI: 1.31, 1.85; HRRecurrence, 1.21; 95% CI: 0.96,1. 52). The association of PLP with improved OS was consistent across colorectal tumor site (right-sided colon: HROS, 0.75; 95% CI: 0.59, 0.96; left-sided colon: HROS, 0.71; 95% CI: 0.55, 0.92; rectosigmoid junction and rectum: HROS, 0.61; 95% CI: 0.47, 0.78).

Conclusion

Higher preoperative vitamin B6 status is associated with improved OS among stage I-III CRC patients.

SUBMITTER: Holowatyj AN

PROVIDER: S-EPMC9348990 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.

Holowatyj Andreana N AN Ose Jennifer J Gigic Biljana B Lin Tengda T Ulvik Arve A Geijsen Anne J M R AJMR Brezina Stefanie S Kiblawi Rama R van Roekel Eline H EH Baierl Andreas A Böhm Jürgen J Bours Martijn J L MJL Brenner Hermann H Breukink Stéphanie O SO Chang-Claude Jenny J de Wilt Johannes H W JHW Grady William M WM Grünberger Thomas T Gumpenberger Tanja T Herpel Esther E Hoffmeister Michael M Keulen Eric T P ETP Kok Dieuwertje E DE Koole Janna L JL Kosma Katharina K Kouwenhoven Ewout A EA Kvalheim Gry G Li Christopher I CI Schirmacher Peter P Schrotz-King Petra P Singer Marie C MC van Duijnhoven Fränzel J B FJB van Halteren Henk K HK Vickers Kathy K Vogelaar F Jeroen FJ Warby Christy A CA Wesselink Evertine E Ueland Per M PM Ulrich Alexis B AB Schneider Martin M Habermann Nina N Kampman Ellen E Weijenberg Matty P MP Gsur Andrea A Ulrich Cornelia M CM

The American journal of clinical nutrition 20220801 2

<h4>Background</h4>Folate-mediated 1-carbon metabolism requires several nutrients, including vitamin B6. Circulating biomarker concentrations indicating high vitamin B6 status are associated with a reduced risk of colorectal cancer (CRC). However, little is known about the effect of B6 status in relation to clinical outcomes in CRC patients.<h4>Objectives</h4>We investigated survival outcomes in relation to vitamin B6 status in prospectively followed CRC patients.<h4>Methods</h4>A total of 2031 ...[more]

PMID: 35394006

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Project description:ImportanceThe associations of B vitamin status with metabolic syndrome (MetS) incidence among the US population remain unclear.ObjectiveTo investigate intakes and serum concentrations of folate, vitamin B6, and vitamin B12 in association with MetS risk in a large US cohort.Design, setting, and participantsThis prospective study included Black and White young adults in the US who were enrolled from 1985 to 1986 and studied until 2015 to 2016. Diet was assessed using a validated diet history at examination years 0, 7, and 20. Serum concentrations of folate, vitamin B6, and vitamin B12 were assayed at examination years 0, 7, and 15 in a subset of 1430 participants. MetS was ascertained by clinic and laboratory measurements and self-reported medication use. Data were analyzed between January and July 2021.ExposuresIntakes and serum levels of folate, vitamin B6, and vitamin B12.Main outcomes and measuresMultivariable Cox proportional hazards regression models were used to calculate hazard ratios (HRs) and 95% CIs for the associations of energy-adjusted B vitamin intakes or serum B vitamin levels with incident MetS.ResultsThe study included 4414 participants, with 2225 Black individuals (50.4%) and 2331 women (52.8%). The mean (SD) age at baseline was 24.9 (3.6) years. A total of 1240 incident MetS cases occurred during the 30 years (mean [SD], 22.1 [9.5] years) of follow-up. Compared with the lowest quintile of each energy-adjusted B vitamin intake, the HRs for incident MetS in the highest quintile were 0.39 (95% CI, 0.31-0.49) for folate (P for trend < .001), 0.61 (95% CI, 0.46-0.81) for vitamin B6 (P for trend = .002), and 0.74 (95% CI, 0.58-0.95) for vitamin B12 (P for trend = .008) after adjustment for potential confounders. Similarly, significant inverse associations were observed in the subset with serum data on these B vitamins (folate: HR, 0.23; 95% CI, 0.17-0.33; P for trend < .001; vitamin B6: HR, 0.48; 95% CI, 0.34-0.67; P for trend < .001; and vitamin B12: HR, 0.70; 95% CI, 0.51-0.96; P for trend = .01).Conclusions and relevanceThis prospective cohort study found that intakes and serum concentrations of folate, vitamin B6, and vitamin B12 were inversely associated with incident MetS among Black and White young adults in the US.

Dataset Information

Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.

Background

Objectives

Methods

Results

Conclusion

Publications

Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.

Similar Datasets

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