Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability and potential clinical benefits.

ABSTRACT:

Background

Dietary changes impact human physiology and immune function and have potential as therapeutic strategies.

Objective

Assess the tolerability of a ketogenic diet (KD) in patients with relapsing multiple sclerosis (MS) and define the impact on laboratory and clinical outcome metrics.

Methods

Sixty-five subjects with relapsing MS enrolled into a 6-month prospective, intention-to-treat KD intervention. Adherence was monitored with daily urine ketone testing. At baseline, fatigue, depression and quality of life (QoL) scores were obtained in addition to fasting adipokines and MS-related clinical outcome metrics. Baseline metrics were repeated at 3 and/or 6 months on-diet.

Results

Eighty-three percent of participants adhered to the KD for the study duration.

SUBMITTER: Brenton JN 

PROVIDER: S-EPMC9350909 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature