<i>Staphylococcus aureus</i> induces a muted host response in human blood that blunts the recruitment of neutrophils.

ABSTRACT: Staphylococcus aureus is an opportunistic pathogen and chief among bloodstream-infecting bacteria. S. aureus produces an array of human-specific virulence factors that may contribute to immune suppression. Here, we defined the response of primary human phagocytes following infection with S. aureus using RNA-sequencing (RNA-Seq). We found that the overall transcriptional response to S. aureus was weak both in the number of genes and in the magnitude of response. Using an ex vivo bacteremia model with fresh human blood, we uncovered that infection with S. aureus resulted in the down-regulation of genes related to innate immune response and cytokine and chemokine signaling. This muted transcriptional response was conserved across diverse S. aureus clo

SUBMITTER: Zwack EE 

PROVIDER: S-EPMC9351360 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature