Preparation of total flavonoids from loquat flower and its protective effect on acute alcohol-induced liver injury in mice.

ABSTRACT: This study aimed to research the preparation techniques of total flavones from loquat flower (TFLF), its anti-oxidation capacity, and its protective effect on hepatic injury. The best extraction parameters by orthogonal experimentation were water at 100°C, extraction time 2.5 hours, solid/liquid ratio 1:20, and three decoctions. The chromogenic reaction to the flavones showed that loquat flowers mainly contained flavone, flavonol, and flavanone compounds combining ortho-phenolic hydroxyl group structure in the 10-30% ethanol fraction. The anti-oxidant capacity of O₂^-· was 26.09% and of OH^-·was 83.01% by salicylic acid and pyrogallol auto-oxidation. Compared with the model group, TFLF lowered the levels of alanine aminotransferase, aspartate aminotransferase

SUBMITTER: Wu SK 

PROVIDER: S-EPMC9351748 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature