Identification of Anti-HIV Biomarkers of Helichrysum Species by NMR-Based Metabolomic Analysis.

ABSTRACT: Several species of the Helichrysum genus have been used ethnobotanically to treat conditions that we today know have been caused by viral infections. Since HIV is a modern disease with no ethnobotanical history, we commenced with a study on the anti-HIV activity of several Helichrysum species. Drug discovery of small molecules from natural resources that is based on the integration of chemical and biological activity by means of metabolomical analyses, enables faster and a more cost-effective path to identify active compounds without the need for a long process of bioassay-guided fractionation. This study used metabolomics to identify anti-HIV compounds as biomarkers from 57 Helichrysum species in a combined study of the chemical and biological data of two previous stu

SUBMITTER: Emamzadeh Yazdi S 

PROVIDER: S-EPMC9355245 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature