Nano-silica particles synergistically IgE-mediated mast cell activation exacerbating allergic inflammation in mice.

ABSTRACT:

Background

Allergic respiratory diseases have increased dramatically due to air pollution over the past few decades. However, studies are limited on the effects of inorganic components and particulate matter with different particle sizes in smog on allergic diseases, and the possible molecular mechanism of inducing allergies has not been thoroughly studied.

Methods

Four common mineral elements with different particle sizes in smog particles were selected, including Al₂O₃, TiO₂, Fe₂O₃, and SiO₂. We studied the relationship and molecular mechanism of smog particle composition, particle size, and allergic reactions using mast cells, immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis (PCA) model, and an

SUBMITTER: Yang YS 

PROVIDER: S-EPMC9355306 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature