High bone mass and cam morphology are independently related to hip osteoarthritis: findings from the High Bone Mass cohort.

ABSTRACT:

Background

High bone mass (HBM, BMD Z-score ≥  + 3.2) and cam morphology (bulging of lateral femoral head) are associated with greater odds of prevalent radiographic hip osteoarthritis (rHOA). As cam morphology is itself a manifestation of increased bone deposition around the femoral head, it is conceivable that cam morphology may mediate the relationship between HBM and rHOA. We therefore aimed to determine if individuals with HBM have increased odds of prevalent cam morphology. In addition, we investigated whether the relationship between cam and prevalent and incident osteoarthritis was preserved in a HBM population.

Methods

In the HBM study, a UK based cohort of adults with unexplained HBM and their relatives and spouses (controls), we determined the presence of cam morp

SUBMITTER: Zucker BE 

PROVIDER: S-EPMC9356486 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature