Prevalence of radiographic hip osteoarthritis is increased in high bone mass.

ABSTRACT:

Objective

Epidemiological studies have shown an association between increased bone mineral density (BMD) and osteoarthritis (OA), but whether this represents cause or effect remains unclear. In this study, we used a novel approach to investigate this question, determining whether individuals with High Bone Mass (HBM) have a higher prevalence of radiographic hip OA compared with controls.

Design

HBM cases came from the UK-based HBM study: HBM was defined by BMD Z-score. Unaffected relatives of index cases were recruited as family controls. Age-stratified random sampling was used to select further population controls from the Chingford and Hertfordshire cohort studies. Pelvic radiographs were pooled and assessed by a single observer blinded to case-control status. Analyses use

SUBMITTER: Hardcastle SA 

PROVIDER: S-EPMC4147962 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature