Genome-Wide Association Study on the Hematological Phenotypic Characteristics of the Han Population from Northwest China.

ABSTRACT:

Background

Hematological characteristics have positive reference value as clinical indicators in the evaluation of various diseases. The purpose of this study was to determine the gene loci associated with 20 hematological phenotypes in the Han population from northwest China.

Methods

A genome-wide association study (GWAS) was conducted on hematological indicators of 1005 Han people from northwest China. Genotyping was performed with a GeneTitan multichannel instrument and Axiom Analysis Suite 6.0. Using the 1000 Genomes Project (phase 3) as a reference, haplotype imputation was performed with IMPUTE2. SNVs (single nucleotide variants) significantly associated with hematological phenotypes were identified. The top SNV (p < 5E-7) was then selected for replication detec

SUBMITTER: Yang W 

PROVIDER: S-EPMC9357418 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature