Elastometry of clot phantoms via magnetomotive ultrasound-based resonant acoustic spectroscopy.

ABSTRACT: Objective.An ultrasound-based system capable of both imaging thrombi against a dark field and performing quantitative elastometry could allow for fast and cost-effective thrombosis diagnosis, staging, and treatment monitoring. This study investigates a contrast-enhanced approach for measuring the Young's moduli of thrombus-mimicking phantoms.Approach.Magnetomotive ultrasound (MMUS) has shown promise for lending specific contrast to thrombi by applying a temporally modulated force to magnetic nanoparticle (MNP) contrast agents and measuring resulting tissue displacements. However, quantitative elastometry has not yet been demonstrated in MMUS, largely due to difficulties inherent in measuring applied magnetic forces and MNP densities. To avoid these issues, in this work magnet

SUBMITTER: Levy BE 

PROVIDER: S-EPMC9359420 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature