Ontology highlight
ABSTRACT:
SUBMITTER: Tsuji A
PROVIDER: S-EPMC9359980 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Tsuji Akihiro A Yamashita Hayato H Hisatomi Osamu O Abe Masayuki M
Scientific reports 20220808 1
Dimerization is critical for transcription factors (TFs) to bind DNA and regulate a wide variety of cellular functions; however, the molecular mechanisms remain to be completely elucidated. Here, we used high-speed atomic force microscopy (HS-AFM) to observe the dimerization process for a photoresponsive TF Photozipper (PZ), which consists of light-oxygen-voltage-sensing (LOV) and basic-region-leucine-zipper (bZIP) domains. HS-AFM visualized not only the oligomeric states of PZ molecules forming ...[more]