Effects of weight loss on bone turnover, inflammatory cytokines, and adipokines in Chinese overweight and obese adults.

ABSTRACT:

Purpose

Plenty of studies have examined the long term effect of weight loss on bone mineral density. This study aimed to explore the effects of 10% weight loss on early changes in bone metabolism as well as the possible influencing factors.

Methods

Overweight and obese outpatients (BMI > 24.0 kg/m²) were recruited from the nutrition clinic and followed a calorie-restricted, high-protein, low-carbohydrate diet program. Dietary intake, body composition, serum procollagen type I N-propeptide (PINP), β-Crosslaps, PTH, 25(OH) VitD, a series of inflammatory cytokines and adipokines were measured for the participants before starting to lose weight and after 10% weight loss (NCT04207879).

Results

A total of 75 participants were enrolled and 37 participants achieved

SUBMITTER: Yu D 

PROVIDER: S-EPMC9360139 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature