Race, sex, and mid-life changes in brain health: Cardia MRI substudy.

ABSTRACT:

Objective

To examine longitudinal race and sex differences in mid-life brain health and to evaluate whether cardiovascular health (CVH) or apolipoprotein E (APOE) ε4 explain differences.

Methods

The study included 478 Black and White participants (mean age: 50 years). Total (TBV), gray (GMV), white (WMV), and white matter hyperintensity (WMH) volumes and GM-cerebral blood flow (CBF) were acquired with 3T-magnetic resonance imaging at baseline and 5-year follow-up. Analyses were based on general linear models.

Results

There were race x sex interactions for GMV (P-interaction = .004) and CBF (P-interaction = .01) such that men showed more decline than women, and this was most evident in Blacks. Blacks compared to Whites had a significantly greater increase in WMH (P = .

SUBMITTER: Moonen JEF 

PROVIDER: S-EPMC9360196 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature