Thrombosis-related circulating miR-16-5p is associated with disease severity in patients hospitalised for COVID-19.
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ABSTRACT:
SUBMITTER: Eyileten C
PROVIDER: S-EPMC9361765 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
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Thrombosis-related circulating miR-16-5p is associated with disease severity in patients hospitalised for COVID-19.
Eyileten Ceren C Wicik Zofia Z Simões Sérgio N SN Martins-Jr David C DC Klos Krzysztof K Wlodarczyk Wojciech W Assinger Alice A Soldacki Dariusz D Chcialowski Andrzej A Siller-Matula Jolanta M JM Postula Marek M
RNA biology 20220101 1
SARS-CoV-2 tropism for the ACE2 receptor, along with the multifaceted inflammatory reaction, is likely to drive the generalized hypercoagulable and thrombotic state seen in patients with COVID-19. Using the original bioinformatic workflow and network medicine approaches we reanalysed four coronavirus-related expression datasets and performed co-expression analysis focused on thrombosis and ACE2 related genes. We identified microRNAs (miRNAs) which play role in ACE2-related thrombosis in coronavi ...[more]
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