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Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy.

ABSTRACT: C₆₀-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhibitor and SICM would be an excellent tool to study the morphological information of adhesive and fragile samples.

SUBMITTER: Ruan H

PROVIDER: S-EPMC9364078 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy.

Ruan Hefei H Zhang Xuejie X Yuan Jinghe J Fang Xiaohong X

RSC advances 20220810 34

C<sub>60</sub>-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhi ...[more]

PMID: 36043103

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