Effects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer's Disease Risk.

ABSTRACT:

Background

The interaction of aging-related, genetic, and environmental factors is thought to contribute to the etiology of late-onset, sporadic Alzheimer's disease (AD). We previously reported that serum levels of p,p'-dichlorodiphenyldichloroethylene (DDE), a long-lasting metabolite of the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT), were significantly elevated in patients with AD and associated with the risk of AD diagnosis. However, the mechanism by which DDT may contribute to AD pathogenesis is unknown.

Objectives

This study sought to assess effects of DDT exposure on the amyloid pathway in multiple in vitro and in vivo models.

Methods

Cultured cells (SH-SY5Y and primary neurons), transgenic flies overexpressing amyloid bet

SUBMITTER: Eid A 

PROVIDER: S-EPMC9364816 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature