Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study.

ABSTRACT:

Background

Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America.

Methods

We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico. Odds ratios (OR) were estimated using conditional logistic regression models. Analyses were stratified by size and hormonal receptor status of the t

SUBMITTER: Fontvieille E 

PROVIDER: S-EPMC9367082 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature