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Autophagy-Associated Immunogenic Modulation and Its Applications in Cancer Therapy.

ABSTRACT: Autophagy, a lysosome-mediated cellular degradation pathway, recycles intracellular components to maintain metabolic balance and survival. Autophagy plays an important role in tumor immunotherapy as a "double-edged sword" that can both promote and inhibit tumor progression. Autophagy acts on innate and adaptive immunity and interacts with immune cells to modulate tumor immunotherapy. The discovery of autophagy inducers and autophagy inhibitors also provides new insights for clinical anti-tumor therapy. However, there are also difficulties in the application of autophagy-related regulators, such as low bioavailability and the lack of efficient selectivity. This review focuses on autophagy-related immunogenic regulation and its application in cancer therapy.

SUBMITTER: Duan Z

PROVIDER: S-EPMC9367255 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Autophagy-Associated Immunogenic Modulation and Its Applications in Cancer Therapy.

Duan Zhuxi Z Shi Yu Y Lin Qun Q Hamaï Ahmed A Mehrpour Maryam M Gong Chang C

Cells 20220728 15

Autophagy, a lysosome-mediated cellular degradation pathway, recycles intracellular components to maintain metabolic balance and survival. Autophagy plays an important role in tumor immunotherapy as a "double-edged sword" that can both promote and inhibit tumor progression. Autophagy acts on innate and adaptive immunity and interacts with immune cells to modulate tumor immunotherapy. The discovery of autophagy inducers and autophagy inhibitors also provides new insights for clinical anti-tumor t ...[more]

PMID: 35954167

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