A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal-Organic Frameworks for Visual Detection of Uric Acid.

ABSTRACT: As an important biomarker in urine, the level of uric acid is of importance for human health. In this work, a Cu(II) functionalized metal-organic framework (Cu²⁺@Tb-MOFs) is designed and developed as a novel fluorescence probe for wide-range uric acid detection in human urine. The study shows that this fluorescence platform demonstrated excellent pH-independent stability, high water tolerance, and good thermal stability. Based on the strong interaction between metal ions and uric acid, the designed Cu²⁺@Tb-MOFs can be employed as efficient turn-on fluorescent probes for the detection of uric acid with wide detection range (0~10⁴ µM) and high sensitivity (LOD = 0.65 µM). This probe also demonstrates an anti-interference property, as other species coexisted,

SUBMITTER: Yang J 

PROVIDER: S-EPMC9369708 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature