Dataset Information

Clinical Features and Prognosis of Young and Middle-Aged Adults With Skin Sebaceous Adenocarcinoma.

ABSTRACT:

Background

Sebaceous adenocarcinoma (SAC) mostly occurs in the elderly, and SAC in young and middle-aged population is inadequately investigated.

Objective

To explore the clinical features and prognosis of young and middle-aged adults with SAC.

Materials and methods

Patients with skin SAC between ages 18 and 59 years from the Surveillance, Epidemiology, and End Results database (1975-2016) were eligible for this study.

Results

Seven hundred thirty-nine cases were identified. The proportion of extraocular SAC in the nonelderly increased from 1975-2005 to 2006-2016 ( p = .001), male predominance was observed in overall patients whereas female predominance in Asian population, and young patients had more head and neck SAC than middle-aged patients ( p = .014). The prognosis of young patients was better than middle-aged patients ( p = .004). Other independent prognostic factors included sex, marital status, tumor size, surgery, chemotherapy, and multiple primary cancer history.

Conclusion

An increasing proportion of extraocular SAC was observed in young and middle-aged patients, and the young developed more head and neck SAC than the middle-aged. Female predominance was found in Asian population, and female patients had better prognosis. Younger age and married status indicated better prognosis, and around 20% of young and middle-aged patients might have poorer survival because of Muir-Torre syndrome.

SUBMITTER: Wang F

PROVIDER: S-EPMC9371062 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Clinical Features and Prognosis of Young and Middle-Aged Adults With Skin Sebaceous Adenocarcinoma.

Wang Fan F Wang Xiu-Yun XY Jiang Xian X

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20220621 8

<h4>Background</h4>Sebaceous adenocarcinoma (SAC) mostly occurs in the elderly, and SAC in young and middle-aged population is inadequately investigated.<h4>Objective</h4>To explore the clinical features and prognosis of young and middle-aged adults with SAC.<h4>Materials and methods</h4>Patients with skin SAC between ages 18 and 59 years from the Surveillance, Epidemiology, and End Results database (1975-2016) were eligible for this study.<h4>Results</h4>Seven hundred thirty-nine cases were ide ...[more]

PMID: 35917259

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Dataset Information

Clinical Features and Prognosis of Young and Middle-Aged Adults With Skin Sebaceous Adenocarcinoma.

Background

Objective

Materials and methods

Results

Conclusion

Publications

Clinical Features and Prognosis of Young and Middle-Aged Adults With Skin Sebaceous Adenocarcinoma.

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