Brain-specific genes contribute to chronic but not to acute back pain.

ABSTRACT:

Introduction

Back pain is the leading cause of disability worldwide. Although most back pain cases are acute, 20% of acute pain patients experience chronic back pain symptoms. It is unclear whether acute pain and chronic pain have similar or distinct underlying genetic mechanisms.

Objectives

To characterize the molecular and cellular pathways contributing to acute and chronic pain states.

Methods

Cross-sectional observational genome-wide association study.

Results

A total of 375,158 individuals from the UK Biobank cohort were included in the discovery of genome-wide association study. Of those, 70,633 (19%) and 32,209 (9%) individuals met the definition of chronic and acute back pain, respectively. A total of 355 single nucleotide polymorphism grouped into 13 l

SUBMITTER: Bortsov AV 

PROVIDER: S-EPMC9371560 | biostudies-literature | 2022 Sep-Oct

REPOSITORIES: biostudies-literature