[Propofol-ketamine versus dexmedetomidine-ketamine for sedation during upper gastrointestinal endoscopy in pediatric patients: a randomized clinical trial].

ABSTRACT:

Background and objectives

Day-case pediatric sedation is challenging. Dexmedetomidine is a sedative analgesic that does not induce respiratory depression. We compared dexmedetomidine to propofol when it was added to ketamine for sedation during pediatric endoscopy, regarding recovery time and hemodynamic changes.

Methods

We enrolled 120 patients (2-7 years in age) and randomly assigned them into two groups. Each patient received intravenous (IV) ketamine at a dose of 1 mg.kg^-1 in addition to either propofol (1 mg.kg^-1) or dexmedetomidine (0.5 μg.kg^-1). The recovery time was compared. Hemodynamics, oxygen saturation, need for additional doses, postoperative complications and endoscopist satisfaction were monitored.

Results

There was no

SUBMITTER: Amer AM 

PROVIDER: S-EPMC9373339 | biostudies-literature | 2020 Nov-Dec

REPOSITORIES: biostudies-literature