Rapid evolution of mutation rate and spectrum in response to environmental and population-genetic challenges.

ABSTRACT: Ecological and demographic factors can significantly shape the evolution of microbial populations both directly and indirectly, as when changes in the effective population size affect the efficiency of natural selection on the mutation rate. However, it remains unclear how rapidly the mutation-rate responds evolutionarily to the entanglement of ecological and population-genetic factors over time. Here, we directly assess the mutation rate and spectrum of Escherichia coli clones isolated from populations evolving in response to 1000 days of different transfer volumes and resource-replenishment intervals. The evolution of mutation rates proceeded rapidly in response to demographic and/or environmental changes, with substantial bidirectional shifts observed as early as 59 generations. These r

SUBMITTER: Wei W 

PROVIDER: S-EPMC9376063 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature