Time-sensitive prognostic performance of an afterload-integrated diastolic index in heart failure with preserved ejection fraction: a prospective multicentre observational study.

ABSTRACT:

Objectives

The prognostic significance of an afterload-integrated diastolic index, the ratio of diastolic elastance (Ed) to arterial elastance (Ea) (Ed/Ea=[E/e']/[0.9×systolic blood pressure]), is valid for 1 year after discharge in older patients with heart failure with preserved ejection fraction (HFpEF). We aimed to clarify the association with changes in Ed/Ea from enrolment to 1 year and prognosis thereafter in patients with HFpEF.

Setting

A prospective, multicentre observational registry of collaborating hospitals in Osaka, Japan.

Participants

We enrolled 659 patients with HFpEF hospitalised for acute decompensated heart failure (men/women: 296/363). Blood tests and transthoracic echocardiography were performed before discharge and at 1 year after.

Primary ou

SUBMITTER: Hoshida S 

PROVIDER: S-EPMC9379494 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature