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Isolation and biosynthesis of daturamycins from Streptomyces sp. KIB-H1544.

ABSTRACT: Two novel diarylcyclopentenones daturamycin A and B (1 and 2), and one new p-terphenyl daturamycin C (3), along with three known congeners (4-6), were isolated from a rhizosphere soil-derived Streptomyces sp. KIB-H1544. The structures of new compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Compounds 1 and 2 belong to a rare class of tricyclic 6/5/6 diarylcyclopentenones, and compounds 3-6 possess a C-18 tricyclic aromatic skeleton. The biosynthetic gene cluster of daturamycins was identified through gene knockout and biochemical characterization experiments and the biosynthetic pathway of daturamycins was proposed.

SUBMITTER: Chen Y

PROVIDER: S-EPMC9379647 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Isolation and biosynthesis of daturamycins from Streptomyces sp. KIB-H1544.

Chen Yin Y Ren Jinqiu J Yang Ruimin R Li Jie J Huang Sheng-Xiong SX Yan Yijun Y

Beilstein journal of organic chemistry 20220809

Two novel diarylcyclopentenones daturamycin A and B (1 and 2), and one new p-terphenyl daturamycin C (3), along with three known congeners (4-6), were isolated from a rhizosphere soil-derived Streptomyces sp. KIB-H1544. The structures of new compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Compounds 1 and 2 belong to a rare class of tricyclic 6/5/6 diarylcyclopentenones, and c ...[more]

PMID: 36051563

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