Hormonal regulation of telomerase activity and hTERT expression in steroid-regulated tissues and cancer.

ABSTRACT: Naturally, in somatic cells chromosome ends (telomeres) shorten during each cell division. This process ensures to limit proliferation of somatic cells to avoid malignant proliferation; however, it leads to proliferative senescence. Telomerase contains the reverse transcriptase TERT, which together with the TERC component, is responsible for protection of genome integrity by preventing shortening of telomeres through adding repetitive sequences. In addition, telomerase has non-telomeric function and supports growth factor independent growth. Unlike somatic cells, telomerase is detectable in stem cells, germ line cells, and cancer cells to support self-renewal and expansion. Elevated telomerase activity is reported in almost all of human cancers. Increased expression of hTERT gene or its re

SUBMITTER: Taheri M 

PROVIDER: S-EPMC9380309 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature