Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study.

ABSTRACT:

Objective

Genome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most loci remain unclear, hampering translation of these genetic discoveries. We aimed to prioritise genes underlying the 110 SLE loci that were identified in the latest East Asian GWAS meta-analysis.

Methods

We built gene expression predictive models in blood B cells, CD4⁺ and CD8⁺ T cells, monocytes, natural killer cells and peripheral blood cells of 105 Japanese individuals. We performed a transcriptome-wide association study (TWAS) using data from the latest genome-wide association meta-analysis of 208 370 East Asians and searched for candidate genes using TWAS and three data-driven computational approaches

SUBMITTER: Yin X 

PROVIDER: S-EPMC9380500 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature