Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility.

ABSTRACT:

Purpose

Recent studies have shown that Ankyrin Repeat Domain 55 (ANKRD55) gene polymorphism is a risk factor for multiple autoimmune diseases, but its association with autoimmune thyroid diseases (AITDs) has not been reported. The purpose of this study was to investigate the potential relationship between polymorphism of the ANKRD55 gene and AITDs.

Methods

For this study, we enrolled 2050 subjects, consisting of 1220 patients with AITD and 830 healthy subjects. Five loci (rs321776, rs191205, rs7731626, rs415407, and rs159572) of the ANKRD55 gene were genotyped using Multiplex PCR combined with high-throughput sequencing.

Results

The results showed that the allele frequencies of rs7731626 and rs159572 loci in HT patients were lower than those in no

SUBMITTER: Fang YD 

PROVIDER: S-EPMC9381225 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature