Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial.

ABSTRACT:

Importance

Preclinical and clinical studies have suggested a neuroprotective effect of remote ischemic conditioning (RIC), which involves repeated occlusion/release cycles on bilateral upper limb arteries; however, robust evidence in patients with ischemic stroke is lacking.

Objective

To assess the efficacy of RIC for acute moderate ischemic stroke.

Design, setting, and participants

This multicenter, open-label, blinded-end point, randomized clinical trial including 1893 patients with acute moderate ischemic stroke was conducted at 55 hospitals in China from December 26, 2018, through January 19, 2021, and the date of final follow-up was April 19, 2021.

Interventions

Eligible patients were randomly assigned within 48 hours after symptom onset to receive treatme

SUBMITTER: Chen HS 

PROVIDER: S-EPMC9382441 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature