Longitudinal Analysis of Memory T cell Responses in Survivors of Middle East respiratory syndrome.

ABSTRACT:

Background

The Middle East respiratory syndrome (MERS) is a highly lethal respiratory disease caused by a zoonotic betacoronavirus. The development of effective vaccines and control measures requires a thorough understanding of the immune response to this viral infection.

Methods

We investigated cellular immune responses up to 5 years after infection in a cohort of 59 MERS survivors by performing ELISPOT assay and intracellular cytokine staining after stimulation of peripheral blood mononuclear cells with synthetic viral peptides.

Results

Memory T cell responses were detected in 82, 75, 69, 64, and 64% of MERS survivors from 1-5 years post-infection, respectively. Although the frequency of virus-specific gamma interferon (IFN-γ)-secreting T cells tended to be higher i

SUBMITTER: Shin HS 

PROVIDER: S-EPMC9383109 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature