Risk Factors and Multidimensional Assessment of Long Coronavirus Disease Fatigue: A Nested Case-Control Study.

ABSTRACT:

Background

Fatigue is the most prevalent and debilitating long-COVID (coronavirus disease) symptom; however, risk factors and pathophysiology of this condition remain unknown. We assessed risk factors for long-COVID fatigue and explored its possible pathophysiology.

Methods

This was a nested case-control study in a COVID recovery clinic. Individuals with (cases) and without (controls) significant fatigue were included. We performed a multidimensional assessment evaluating various parameters, including pulmonary function tests and cardiopulmonary exercise testing, and implemented multivariable logistic regression to assess risk factors for significant long-COVID fatigue.

Results

A total of 141 individuals were included. The mean age was 47 (SD: 13) years; 115 (82%) wer

SUBMITTER: Margalit I 

PROVIDER: S-EPMC9383780 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature