Dataset Information

BNT162b2 mRNA Vaccination Against COVID-19 is Associated with Decreased Likelihood of Multisystem Inflammatory Syndrome in U.S. Children Ages 5-18 Years.

ABSTRACT:

Background

Multisystem inflammatory syndrome in children (MIS-C), linked to antecedent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with considerable morbidity. Prevention of SARS-CoV-2 infection or coronavirus disease 2019 (COVID-19) by vaccination might also decrease MIS-C likelihood.

Methods

In a multicenter case-control public health investigation of children ages 5-18 years hospitalized from July 1, 2021 to April 7, 2022, we compared the odds of being fully vaccinated (two doses of BNT162b2 vaccine ≥28 days before hospital admission) between MIS-C case-patients and hospital-based controls who tested negative for SARS-CoV-2. These associations were examined by age group, timing of vaccination, and periods of Delta and Omicron variant predominance using multivariable logistic regression.

Results

We compared 304 MIS-C case-patients (280 [92%] unvaccinated) with 502 controls (346 [69%] unvaccinated). MIS-C was associated with decreased likelihood of vaccination (aOR, 0.16 95% CI, 0.10-0.26), including among children ages 5-11 years (aOR, 0.22 95% CI, 0.10-0.52), ages 12-18 years (aOR, 0.10 95% CI, 0.05-0.19), and during the Delta (aOR, 0.06 95% CI, 0.02-0.15) and Omicron (aOR, 0.22 95% CI, 0.11-0.42) variant-predominant periods. This association persisted beyond 120 days after the second dose (aOR, 0.08, 95% CI, 0.03-0.22) in 12-18 year-olds. Among all MIS-C case-patients, 187 (62%) required intensive care unit admission and 280 (92%) vaccine-eligible patients were unvaccinated.

Conclusions

Vaccination with two doses of BNT162b2 is associated with reduced likelihood of MIS-C in children ages 5-18 years. Most vaccine eligible hospitalized patients with MIS-C were unvaccinated.

SUBMITTER: Zambrano LD

PROVIDER: S-EPMC9384630 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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BNT162b2 mRNA Vaccination Against Coronavirus Disease 2019 is Associated With a Decreased Likelihood of Multisystem Inflammatory Syndrome in Children Aged 5-18 Years-United States, July 2021 - April 2022.

Zambrano Laura D LD Newhams Margaret M MM Olson Samantha M SM Halasa Natasha B NB Price Ashley M AM Orzel Amber O AO Young Cameron C CC Boom Julie A JA Sahni Leila C LC Maddux Aline B AB Bline Katherine E KE Kamidani Satoshi S Tarquinio Keiko M KM Chiotos Kathleen K Schuster Jennifer E JE Cullimore Melissa L ML Heidemann Sabrina M SM Hobbs Charlotte V CV Nofziger Ryan A RA Pannaraj Pia S PS Cameron Melissa A MA Walker Tracie C TC Schwartz Stephanie P SP Michelson Kelly N KN Coates Bria M BM Flori Heidi R HR Mack Elizabeth H EH Smallcomb Laura L Gertz Shira J SJ Bhumbra Samina S SS Bradford Tamara T TT Levy Emily R ER Kong Michele M Irby Katherine K Cvijanovich Natalie Z NZ Zinter Matt S MS Bowens Cindy C Crandall Hillary H Hume Janet R JR Patel Manish M MM Campbell Angela P AP Randolph Adrienne G AG

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20230201 3

<h4>Background</h4>Multisystem inflammatory syndrome in children (MIS-C), linked to antecedent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is associated with considerable morbidity. Prevention of SARS-CoV-2 infection or coronavirus disease 2019 (COVID-19) by vaccination might also decrease MIS-C likelihood.<h4>Methods</h4>In a multicenter, case-control, public health investigation of children ages 5-18 years hospitalized from 1 July 2021 to 7 April 2022, we compared t ...[more]

PMID: 35924406

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