[Expression and significance of fibroblast growth factor receptor 2 in clear cell renal cell carcinoma].

ABSTRACT:

Objective

To investigate the expression of fibroblast growth factor receptor 2 (FGFR2) in clear cell renal cell carcinoma (ccRCC; or kidney renal clear cell carcinoma, KIRC), to analyze the relationship between the expression of FGFR2 and the clinical pathological features and prognosis of ccRCC, to study the relationship between the expression of FGFR2 and other molecules, and to explore its role in the development of ccRCC.

Methods

Gene expressional and clinical information of ccRCC patients were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus(GEO) database. Next, the data were transformed and collated. In the study, 104 clinical ccRCC samples and corresponding paracancerous normal tissue samples were collected from Department of Ur

SUBMITTER: Cai TY 

PROVIDER: S-EPMC9385531 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature