A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis.

ABSTRACT:

Background and aims

Hepatoblastoma (HB) is the most common pediatric liver cancer. Its predominant occurrence in very young children led us to investigate whether the neonatal liver provides a protumorigenic niche to HB development.

Approach and results

HB development was compared between orthotopic transplantation models established in postnatal day 5 (P5) and 60 (P60) mice (P5^Tx and P60^Tx models). Single-cell RNA-sequencing (sc-RNAseq) was performed using tumor and liver tissues from both models and the top candidate cell types and genes identified are investigated for their roles in HB cell growth, migration, and survival.

Conclusions

We found that various HB cell lines including HepG2 cells were consistently and considerably more tumorigenic

SUBMITTER: Fan L 

PROVIDER: S-EPMC9385889 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature