Separation surgery followed by stereotactic ablative radiotherapy for metastatic epidural spinal cord compression: A systematic review and meta-analysis for local progression rate.

ABSTRACT:

Introduction

Spinal metastasis is the most common metastatic skeletal disease in cancer patients. Metastatic epidural spinal cord compression (MESCC), which occurs in 5-14% of cancer patients, is an oncological emergency because it may cause a permanent neurological deficit. Separation surgery followed by stereotactic ablative radiotherapy (SABR), so-called "hybrid therapy," has shown effectiveness in local control of spinal metastasis and has become an integral treatment option for patients with MESCC. Therefore, we performed a meta-analysis and meta-regression analysis to clarify the local progression rate of hybrid therapy and the risk factors for local progression.

Methods

We searched PubMed, EMBASE, Scopus, Cochrane Library, and Web of Science databases from inception t

SUBMITTER: Kang DH 

PROVIDER: S-EPMC9386097 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature