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Surgery for acromegaly: Indications and goals.


ABSTRACT: Acromegaly is a disease that occurs secondary to high levels of GH, most often from a hormone-secreting pituitary adenoma, with multisystem adverse effects. Diagnosis includes serum GH and IGF-1 levels, and obtaining an MRI pituitary protocol to assess for a functional pituitary adenoma. Attempted gross total resection of the GH-secreting adenoma is the gold standard in treatment for patients with acromegaly for a goal of biochemical remission. Medical and radiation therapies are available when patients do not achieve biochemical cure after surgical therapy.

SUBMITTER: Bray DP 

PROVIDER: S-EPMC9386525 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Surgery for acromegaly: Indications and goals.

Bray David P DP   Mannam Sai S   Rindler Rima S RS   Quillin Joseph W JW   Oyesiku Nelson M NM  

Frontiers in endocrinology 20220804


Acromegaly is a disease that occurs secondary to high levels of GH, most often from a hormone-secreting pituitary adenoma, with multisystem adverse effects. Diagnosis includes serum GH and IGF-1 levels, and obtaining an MRI pituitary protocol to assess for a functional pituitary adenoma. Attempted gross total resection of the GH-secreting adenoma is the gold standard in treatment for patients with acromegaly for a goal of biochemical remission. Medical and radiation therapies are available when  ...[more]

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