Dataset Information

The role of lifestyle factors on comorbidity of chronic liver disease and cardiometabolic disease in Chinese population: A prospective cohort study.

ABSTRACT:

Background

Lifestyle factors are associated with chronic liver disease (CLD) and death after CLD diagnosis. However, their associations with pathways of CLD progression have been unclear, particularly transition to cardiometabolic disease (CMD), a major comorbid condition with CLD. We assessed the associations of lifestyle factors with CLD progression.

Methods

The study population involved 486,828 participants of the prospective China Kadoorie Biobank (CKB) aged 30-79 years without a history of cardiovascular disease, diabetes, CLD, or cancer at baseline. Liver-cardiometabolic comorbidity (LCC) was defined as developing CMD subsequently after first CLD (FCLD) in an individual. A multi-state model was used to estimate the associations of high-risk lifestyle factors (smoking, alcohol, physical inactivity, and central adiposity) with CLD progression from healthy to FCLD, subsequently to LCC, and further to death.

Findings

During a median follow-up of 11 years, 5046 participants developed FCLD, 519 developed LCC, and 157 died afterwards. There were positive associations between the number of high-risk lifestyle factors and risks of all transitions. The hazard ratios (95% CIs) per 1-factor increase were 1.30 (1.25-1.35) for transitions from baseline to FCLD, 1.21 (1.09-1.34) for FCLD to LCC, 1.20 (1.17-1.23) for baseline to death, 1.15 (1.09-1.22) for FCLD to death, and 1.17 (1.06-1.31) for LCC to death. For CLD subtypes, lifestyle factors showed different associations with disease-specific transitions even within the same transition stage.

Interpretation

High-risk lifestyle factors played a key role in all disease transition stages from healthy to FCLD, subsequently to LCC, and then to death, with different magnitude of associations.

Funding

Kadoorie Charitable Foundation, Chinese MoST and NSFC.

SUBMITTER: Pang Y

PROVIDER: S-EPMC9386629 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

The role of lifestyle factors on comorbidity of chronic liver disease and cardiometabolic disease in Chinese population: A prospective cohort study.

Pang Yuanjie Y Han Yuting Y Yu Canqing C Kartsonaki Christiana C Guo Yu Y Chen Yiping Y Yang Ling L Du Huaidong H Hou Wei W Schmidt Danile D Stevens Rebecca R Chen Junshi J Chen Zhengming Z Lv Jun J Li Liming L

The Lancet regional health. Western Pacific 20220810

<h4>Background</h4>Lifestyle factors are associated with chronic liver disease (CLD) and death after CLD diagnosis. However, their associations with pathways of CLD progression have been unclear, particularly transition to cardiometabolic disease (CMD), a major comorbid condition with CLD. We assessed the associations of lifestyle factors with CLD progression.<h4>Methods</h4>The study population involved 486,828 participants of the prospective China Kadoorie Biobank (CKB) aged 30-79 years withou ...[more]

PMID: 35991535

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Dataset Information

The role of lifestyle factors on comorbidity of chronic liver disease and cardiometabolic disease in Chinese population: A prospective cohort study.

Background

Methods

Findings

Interpretation

Funding

Publications

The role of lifestyle factors on comorbidity of chronic liver disease and cardiometabolic disease in Chinese population: A prospective cohort study.

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